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Knowledge sharing and collaboration in translational research, and the DC-THERA Directory.

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TitleKnowledge sharing and collaboration in translational research, and the DC-THERA Directory.
Publication TypeJournal Article
Year of Publication2011
AuthorsSplendiani, A., M. G√ľndel, J. M. Austyn, D. Cavalieri, C. Scognamiglio, and M. Brandizi
JournalBrief Bioinform
Volume12
Issue6
Pagination562-75
Date Published2011 Nov
ISSN1477-4054
KeywordsDatabase Management Systems, Information Dissemination, Information Storage and Retrieval, Internet, Semantics, Translational Medical Research
Abstract

Biomedical research relies increasingly on large collections of data sets and knowledge whose generation, representation and analysis often require large collaborative and interdisciplinary efforts. This dimension of 'big data' research calls for the development of computational tools to manage such a vast amount of data, as well as tools that can improve communication and access to information from collaborating researchers and from the wider community. Whenever research projects have a defined temporal scope, an additional issue of data management arises, namely how the knowledge generated within the project can be made available beyond its boundaries and life-time. DC-THERA is a European 'Network of Excellence' (NoE) that spawned a very large collaborative and interdisciplinary research community, focusing on the development of novel immunotherapies derived from fundamental research in dendritic cell immunobiology. In this article we introduce the DC-THERA Directory, which is an information system designed to support knowledge management for this research community and beyond. We present how the use of metadata and Semantic Web technologies can effectively help to organize the knowledge generated by modern collaborative research, how these technologies can enable effective data management solutions during and beyond the project lifecycle, and how resources such as the DC-THERA Directory fit into the larger context of e-science.

DOI10.1093/bib/bbr051
Alternate JournalBrief. Bioinformatics
Full Text
PubMed ID21969471

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